幽门螺杆菌(Helicobacter pylori,Hp)是导致胃黏膜损伤,引起慢性胃炎、胃溃疡、十二指肠溃疡的重要致病因素。近年 Hp 被分为两个主要类型,第一型为高毒力株,具有 cagA、表达 cagA 蛋白及vacA,此型约占56%.第二型为低毒力株,无cagA、不表达 cagA 蛋白及 vacA,此型约占6%,另外尚有28%属中间型,仅表达 cagA 或 vacA。本研究通过免疫印记法测定 ap 类型,以研究其主要毒力分型与相关胃疾病的关系。 Helicobacter pylori (Hp) is an important causative factor of gastric mucosal injury, chronic gastritis, gastric ulcer and duodenal ulcer. In recent years, Hp is divided into two main types, the first type is a highly virulent strain with cagA, expression of cagA protein and vacA, this type accounts for about 56%. The second type is a low virulent strain, no cagA, no cagA Protein and vacA, this type accounts for about 6%, while another 28% are intermediate, only cagA or vacA expression. In this study, ap type was determined by immunoblotting to study the relationship between the major virulence types and the related gastric diseases.