垂体-肾上腺皮质系统对胃泌素分泌的影响及其在溃疡病发病机理中的作用,日益受到重视。以皮质醇给大鼠肌注,连续7天后,大鼠空腹血清胃泌素值无显著改变,但进餐后激发值较注射前对照值显著增高。本工作提示在长期使用皮质醇作用下,可使G-细胞对进餐刺激的反应增强。 The effect of the pituitary-adrenocortical system on the secretion of gastrin and its role in the pathogenesis of ulcer disease has received increasing attention. After intramuscular injection of cortisol to rats, there was no significant change in fasting serum gastrin values ​​after 7 days of continuous administration, but the post-meal challenge value was significantly higher than the pre-injection control value. This work suggests that G-cell responses to meal stimuli can be enhanced by long-term use of cortisol.