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目的 观察高原肺水肿患者抗氧化能力及内皮功能的变化 ,探讨其变化对高原肺水肿发生、发展的影响。方法 对 34例高原肺水肿患者进行治疗前、治愈后超氧化物歧化酶 (SOD)、丙二醛 (MDA)、还原型谷胱甘肽 (GSH)、一氧化氮 (NO)、一氧化氮合酶 (NOS)含量测定 ,并与 2 0名高原正常健康人作比较。结果 高原肺水肿患者血清SOD、GSH、NO及NOS含量在治疗前显著低于治愈后和对照组 (P <0 0 1) ,MDA及内皮素 1(ET 1)含量治疗前显著高于治愈后和对照组 (P <0 0 1) ,治愈后与对照组差异无显著性 (P >0 0 5 )。结论 高原肺水肿患者机体处于氧化胁迫状态 ,脂质过氧化损伤及内皮功能失衡是造成高原肺水肿的重要机制之一 ,对高原肺水肿的发生、发展及转归产生一定的影响
Objective To observe the changes of antioxidant capacity and endothelial function in patients with high altitude pulmonary edema and to explore the effect of these changes on the occurrence and development of high altitude pulmonary edema. Methods Thirty-four patients with pulmonary edema in the plateau were treated with the drugs before and after the treatment. The levels of superoxide dismutase (SOD), malondialdehyde (MDA), reduced glutathione (GSH), nitric oxide (NO), nitric oxide Synthase (NOS) content was measured and compared with 20 normal healthy highland. Results The levels of serum SOD, GSH, NO and NOS in patients with high altitude pulmonary edema were significantly lower than those in the control group (P <0.01), and the levels of MDA and ET 1 were significantly higher than those before treatment And control group (P <0.01). There was no significant difference between the control group and the cured group (P> 0.05). Conclusion The body of patients with plateau pulmonary edema is in the state of oxidative stress. Lipid peroxidation and imbalance of endothelial function are one of the most important mechanisms that cause plateau pulmonary edema, which may have an impact on the occurrence, development and outcome of plateau pulmonary edema