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以高脂膳食２０周诱导ＳＤ大鼠高胆固醇血症及塑造动脉粥样硬化（ＡＳ）早期病变模型。观察有氧运动对实验性高胆固醇血症大鼠血胆固醇（ＣＨＯ），脂质过氧化物（ＬＰＯ）含量和超氧化物歧化酶（ＳＯＤ）活性的影响，扫描结合透射电镜观察腹主动脉血管内膜超微结构改变。发现，高胆固醇血症伴随脂质过氧化反应增强，抗氧化酶活性降低，血管内皮细胞（ＥＣ）损伤呈ＡＳ早期改变特征。运动可明显控制高胆固醇血症，增高ＳＯＤ活性，一定程度上控制和／或减轻脂质过氧化物对ＥＣ损伤。提示，运动性抗氧化能力提高对防治ＡＳ早期病变有积极作用。
High-fat diet for 20 weeks was used to induce hypercholesterolemia in SD rats and model early stage of atherosclerosis (AS). To observe the effects of aerobic exercise on blood cholesterol (CHO), lipid peroxidation (LPO) and superoxide dismutase (SOD) activity in experimental hypercholesterolemic rats. Scanning combined with transmission electron microscopy Endometrial ultrastructure changes. It was found that hypercholesterolemia accompanied by increased lipid peroxidation, decreased antioxidant enzyme activity, vascular endothelial cell (EC) damage was characterized early changes in AS. Exercise significantly controls hypercholesterolemia, increases SOD activity, and to some extent controls and / or reduces lipid peroxidation-induced EC damage. Tip, increased exercise antioxidant capacity of prevention and treatment of early stage AS has a positive effect.