论文部分内容阅读
通过抗鼠疫血清、鼠疫噬菌体、抗鼠疫噬体血清及吖啶黄的人工培养基对鼠疫强毒菌株诱变,获得了9株非典型鼠疫菌株,对其进行了生物学特性研究。采用部分非典型鼠疫菌株做了动物(豚鼠)试验,通过动物模型对带菌时间、部位及突变和返祖过程进行了研究。本文建立了诱变方法及非典型鼠疫菌的检测方法。提出了非典型鼠疫菌的流行病学意义和鼠疫监测对策以及以非典型鼠疫菌作为一种形式在自然界长期保存循环的可能性,并为根除鼠疫自然疫源性提供了一种评价方法和指征。
Ninety atypical Yersinia strains were obtained by mutagenesis of virulent anti-plague strains, anti-plague phage, anti-plague serum and acridine yellow artificial medium, and their biological characteristics were studied. A part of atypical Yersinia pestis strains were used as animal (guinea pig) test. The animal model was used to study the time, location, mutation and return process of the bacteriostasis. In this paper, mutagenesis methods and detection methods of atypical Yersinia pestis were established. The epidemiological significance of the atypical Yersinia pestis and the countermeasure of plague prevention as well as the possibility of using the atypical Yersinia pestis as a form for long-term preservation cycle in nature are proposed, and an evaluation method and means are provided for eradicating the natural foci of plague Levy