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目的对比卡维地洛和美托洛尔治疗两种不同类型的β-受体阻滞剂对慢性心力衰竭的临床疗效。方法将88例慢性心力衰竭患者在常规治疗心力衰竭基础上随机分为卡维地洛组(n=44例)和美托洛尔组(n=44例),随治6～12个月观察两组治疗前后血流动力学、左室舒张末期内径(LVEDD)、左室收缩末期内径(LVESD)、左室射血分数(LVEF)及心功能变化。结果两组治疗后,卡维地洛组在血流动力学的心功能改善上较美托洛尔组疗效明显(P<0.05),但治疗后组间心率降低,差异无统计学意义(P>0.05)。结论卡维地洛在治疗慢性心力衰竭中安全有效且疗效较美托洛尔更显著。
Objective To compare the clinical effects of carvedilol and metoprolol on two different types of β-blockers in patients with chronic heart failure. Methods Eighty-eight patients with chronic heart failure were randomly divided into two groups: carvedilol group (n = 44) and metoprolol group (n = 44). The patients were followed up for 6 to 12 months Group before and after treatment hemodynamics, left ventricular end-diastolic diameter (LVEDD), left ventricular end-systolic diameter (LVESD), left ventricular ejection fraction (LVEF) and cardiac function changes. Results After treatment, the effect of carvedilol on the improvement of hemodynamics was significantly better than that of metoprolol (P <0.05), but there was no significant difference between the two groups after treatment (P > 0.05). Conclusion Carvedilol is more effective and effective than metoprolol in the treatment of chronic heart failure.