目的：初步观察西拉普利和牛磺酸对慢性缺氧肺组织细胞凋亡的影响。方法：采用原位末端标记法。结果：缺氧模型及西拉普利组细胞凋亡明显高于其他各组（Ｐ＜０．０１），而牛磺酸组、自然恢复组则与正常对照无差异。结论：西拉普利可能诱发细胞凋亡的作用，细胞凋亡的发生与否可能与肺动脉高压的形成与发展有关。 Objective: To observe the effects of cilazapril and taurine on the apoptosis of lung tissue in chronic hypoxic lung. Methods: In situ end labeling was used. Results: Apoptosis was significantly higher in hypoxia model and cilazapril group than in other groups (P <0.01), while there was no difference between taurine group and spontaneous recovery group. Conclusion: Cilazapril may induce apoptosis and the occurrence of apoptosis may be related to the formation and development of pulmonary hypertension.