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目的 :探讨恶性心包积液经导管引流并腔内化疗的疗效及不良反应。方法 :2 8例恶性心包积液采用B超定位心包穿刺置管引流心包积液 ,连续 3d ,积液消失后第 1d以 0 .9%氯化钠溶液冲洗并腔内注射顺铂 (DDP) 6 0mg ,OK 4 32 10g、地塞米松 5mg心包腔内注射。 结果 :腔内化疗 1次积液消失者 3例 ,化疗 2次积液消失 12例 ,化疗 3次积液消失 6例 ,CR 75 %( 2 1/ 2 8) ,PR 14 .3% ( 4 / 2 8) ,RR 89.3% ( 2 5 / 2 8) ,NC 10 .7% ( 3/ 2 8)。结论 :导管置管治疗恶性心包积液 ,操作简单 ,疗效好 ,副作用少。
Objective: To investigate the efficacy and adverse reactions of malignant pericardial effusion by catheter drainage and intra-luminal chemotherapy. METHODS: Twenty-eight cases of malignant pericardial effusion were treated by percutaneous transhepatic pericardial effusion with B-pericardiocentesis. The peritoneal effusion was induced by continuous infusion of cisplatin (DDP) 60mg, OK 4 32 10g, dexamethasone 5mg pericardial cavity injection. Results: There were 3 cases of primary effusion disappeared after chemotherapy, 12 cases of secondary effusion disappeared after chemotherapy, 6 cases disappeared after 3 cycles of chemotherapy, with CR 75% (21/28) and PR 14.3% (4) / 2 8), RR 89.3% (2 5/2 8), and NC 10.7% (3/28). Conclusion: Catheter catheterization in the treatment of malignant pericardial effusion has the advantages of simple operation, good curative effect and few side effects.