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患者为一4个月的婴儿,患维尔和肠炎杆菌(Salmoaella virchow)脑膜炎,曾联用氯霉素和庆大霉素以及氯霉素和氨苄青霉素治疗无效,后用甲氧苄氨嘧啶(TMP)和磺胺嘧啶静注治愈。TMP对此菌株的体外最小抑菌浓度为0.125微克/毫升。TMP静注剂量开始为10毫克/公斤/24小时(30毫克每日2次),2小时后脑脊液浓度达0.6微克/毫升,后剂量增至16毫克/公斤/24小时(50毫克每日2次),脑脊液浓度达1.4微克/毫升。上述较小剂量连用10天,较大剂量连用1个月,未见毒性。虽然此文仅报告1例的治疗经验,但其重要意义在于它再次表明,TMP和磺胺
The patient was a 4-month-old infant with Viral and Salmoaella virchulent meningitis, had been treated with chloramphenicol and gentamicin, and chloramphenicol and ampicillin, and then treated with trimethoprim ( TMP) and sulfadiazine intravenous cure. The minimum in vitro inhibitory concentration of TMP against this strain was 0.125 μg / ml. TMP intravenous doses started at 10 mg / kg / 24 h (30 mg twice daily), cerebrospinal fluid concentration 0.6 g / ml after 2 hours and then 16 mg / kg / 24 h (50 mg daily 2 Times), CSF concentration of 1.4 μg / ml. The smaller dose of 10 days in a row, the larger dose for 1 month, no toxicity. Although this article reports only one case of treatment experience, but its significance is that it once again shows that TMP and sulfa