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本文对旱柳叶的化学成分及其生物活性进行了研究,从中分离鉴定出11种单体化合物并对其中3种化合物,即芹菜素-7-O-β-D-吡喃葡萄糖醛酸甙(I)、木樨草素-7-O-β-D-吡喃葡萄糖醛酸甙(Ⅱ)、间-羟基-苄基-吡喃葡萄糖成(Ⅲ)的生物活性进行了考察.化合物Ⅰ、Ⅱ、Ⅲ均可选择性抑制花生四烯酸代谢产物12-HETE的生成;化合物(Ⅰ)水解后的甙元——芹菜素对TXB_2的生成有一定的抑制作用,但对12-HETE的生成无抑制作用. 小鼠饲喂高脂肪饲料,一周以后体重即明显增加.饲养高脂肪饲料添加柳活性组分抑制小鼠体重和子宫周围脂肪量的增加,而且还可以降低肝中胆固醇和中性脂肪的含量.化合物Ⅲ对大鼠脂肪细胞中由去甲肾上腺素(NE)诱导的脂类分解有促进作用。
In this paper, the chemical constituents and biological activities of S. matsudana leaves were studied, 11 kinds of monomeric compounds were isolated and identified, and 3 of them were identified, ie, apigenin-7-O-β-D-glucuronopyronate. (I), the biological activity of luteolin-7-O-β-D-glucuronopyranoate ruthenium (II), m-hydroxy-benzyl-glucopyranose (III) was investigated. Compounds I, II, and III can all selectively inhibit the production of 12-HETE, a metabolite of arachidonic acid. The hydrolysis of compound (I), apigenin, has a certain inhibitory effect on the production of TXB2, but it can be used for 12- HETE generation has no inhibitory effect. When mice were fed high-fat diets, body weight increased significantly after one week. Feeding high-fat diets to increase the active components of the willow inhibits the body weight of the mice and increases the amount of fat around the uterus, and can also reduce the content of cholesterol and neutral fat in the liver. Compound III promotes norepinephrine (NE)-induced lipolysis in rat adipocytes.