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目的:对中药静脉给药引起的药物不良反应病例进行分析。方法:采集北京医科大学附属北京朝阳医院1995年1月至2001年12月自发呈报的病例,从性别、年龄、原发疾病、临床表现加以分析。结果:①以60岁以上的老年患者为主,占病例数的33％,②ADR发生时间最短的为2分钟,最长的为7天,③原发疾病以心脑血管疾病为首,其次是感染性疾病,④中药注射剂对人体的损害累及到消化系统、神经系统、循环系统、皮肤及附件等器官,以皮肤反应、神经系统和呼吸系统的反应为主,⑤诱发ADR的药物以活血化瘀改善血液循环的血管扩张药为首,其次是抗感染药物。结论:①中药注射液是临床用于治疗心脑血管疾病的重要药物之一,老年人因多患有心脑血管疾病,是接受此类药物的主要群体,②老年人患有多种疾病,在药物治疗中,因合并用药及特有的生理条件等与ADR的发生密切相关。③给药途径与不良反应有关。
Objective: To analyze the cases of adverse drug reactions caused by intravenous administration of Chinese medicine. METHODS: Spontaneously reported cases from January 1995 to December 2001 in Beijing Chaoyang Hospital, Beijing Medical University were collected and analyzed by gender, age, primary disease, and clinical manifestations. Results: 1 The majority of elderly patients over 60 years old, accounting for 33% of the number of cases, 2 ADR occurs the shortest time is 2 minutes, the longest is 7 days, 3 primary diseases led by cardiovascular and cerebrovascular diseases, followed by infection Sexual diseases, 4 The damage to the body caused by traditional Chinese medicine injections affects the digestive system, nervous system, circulatory system, skin and attachments, etc., and mainly responds to skin reactions, nervous system, and respiratory system. 5 Drugs that induce ADR to activate blood circulation Vascular vasodilators improve blood circulation, followed by anti-infective drugs. Conclusions: 1 Chinese medicine injection is one of the important drugs for the treatment of cardiovascular and cerebrovascular diseases. The elderly suffer from cardiovascular and cerebrovascular diseases and is the main group to receive such drugs. 2 The elderly suffer from multiple diseases. In drug treatment, the occurrence of ADR is closely related to the combination of drugs and unique physiological conditions. 3 The route of administration is related to adverse reactions.