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目的 探讨降纤酶治疗急性脑梗死患者血浆 D-二聚体水平的变化以证实其溶栓作用。 方法 采用前瞻性、随机、双盲对照方法。将 70例急性脑梗死病人分为治疗组和对照组 ,分别于治疗前和治疗后第 6天测血浆纤维蛋白原和 D-二聚体。 结果 治疗组血浆纤维蛋白原治疗后比治疗前有明显下降 ,两者比较有明显的差异 ( P <0 .0 1 )。血浆 D-二聚体治疗后比治疗前有明显的增高 ,两者比较有明显的差异 ( P<0 .0 1 )。而对照组均无明显差异 ( P >0 .0 5)。 结论 降纤酶通过诱发体内 t-PA释放和增强 t-PA活性而产生明显的溶栓作用。
Objective To investigate the changes of plasma D-dimer levels in defibrase-treated patients with acute cerebral infarction in order to confirm the thrombolytic effect. Methods A prospective, randomized, double-blind, controlled trial was performed. Seventy patients with acute cerebral infarction were divided into treatment group and control group, and plasma fibrinogen and D-dimer were measured before treatment and on the 6th day after treatment respectively. Results After treatment, the plasma fibrinogen level in treatment group decreased significantly compared with that before treatment, with significant difference (P <0.01). Plasma D-dimer after treatment than before treatment significantly increased, the two were significantly different (P <0.01). The control group showed no significant difference (P> 0.05). Conclusion Defibrase can induce thrombolysis by inducing t-PA release and enhancing t-PA activity in vivo.