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为探讨妊高征胎盘形态计量学特点，应用图像分析系统对２９例重度妊高征（妊高征组）和２９例正常妊娠（对照组）的胎盘床血管和胎盘绒毛进行形态计量学检测。结果：妊高征组胎盘绒毛具有合体细胞结节、细胞滋养细胞增生、绒毛基底膜增厚、纤维素样坏死和血管合体细胞膜的绒毛数与对照组相比差异显著（Ｐ＜００５）。妊高征组胎盘绒毛直径、周长和面积参数均显著低于对照组（Ｐ＜００５）。妊高征组胎盘床螺旋动脉妊娠生理性改变缺乏，管壁增厚、纤维素样坏死和急性动脉粥样化的发生率显著高于对照组（Ｐ＜００５）。妊高征组ＩＵＧＲ和围产儿病死率显著高于对照组（Ｐ＜００５）。提示胎盘床血管和胎盘形态学病变在妊高征的发病中可能起重要作用。
In order to investigate the characteristics of placenta morphology in pregnancy induced hypertension (PIH), the placental vascular and placental villi of 29 patients with severe PIH and 29 normal controls (control group) were examined by histomorphometry using image analysis system. Results: The placental villi of pregnancy induced hypertension group had significant differences (P <005) compared with the control group, with the number of syncytial nodules, the proliferation of cytotrophoblast cells, the thickening of the basement membrane of villi, the fibrinoid necrosis and the villus number of vascular syncytial cell membrane . The placental villus diameter, circumference and area parameters in PIH group were significantly lower than those in control group (P <005). Pregnancy-induced hypertension group placental spiral placental pregnancy physiological changes in the lack of wall thickening, fibrosis-like necrosis and acute atherosclerosis was significantly higher than the incidence of the control group (P <0 05). PIH patients with IUGR and perinatal mortality was significantly higher than the control group (P <0 05). Prompt placental vascular and placental morphological lesions in the pathogenesis of pregnancy-induced hypertension may play an important role.