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目的 观察降纤酶合尼莫地平治疗急性脑梗塞的临床疗效及相关生化指标 ,探讨降纤抗栓复流和脑保护在急性脑梗塞治疗中的必要性。方法 对符合条件的病例随机分 2组 ,治疗组予降纤酶加尼莫地平治疗 ,对照组予血栓通加胞二磷胆碱治疗 ,分别对其疗效 ,血液流变学 ,凝血酶原时间进行比较。结果 治疗组临床疗效及血流变学指标改善明显 ,且无增加副作用。结论 降纤酶有降纤抗凝溶栓作用 ,尼莫地平抑制Ca2 + 内流保护脑细胞 ,同时有改善血液流变性 ,两药联合应用治疗急性脑梗塞有协同作用 ,可增加疗效
Objective To observe the clinical effects and related biochemical indexes of defibrase and nimodipine in the treatment of acute cerebral infarction and to explore the necessity of anti-fibrinolysis and antithrombotic regurgitation and cerebral protection in the treatment of acute cerebral infarction. Methods The eligible patients were randomly divided into two groups, the treatment group was treated with defibrase plus nimodipine, and the control group was given Xuezhuan plus citicoline treatment. The curative effect, hemorheology, prothrombin time Compare. Results The clinical curative effect and hemorrheological index of the treatment group improved significantly without any side effects. Conclusion Defibrase has anti-fibrinolytic and thrombolytic effects. Nimodipine inhibits the influx of Ca2 + to protect brain cells and improves hemorrheological properties. Synergistic effect of two drugs in the treatment of acute cerebral infarction can increase the curative effect