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目的观察以机械通气为主治疗严重胸外伤所致呼吸窘迫综合征的临床疗效。方法将符合病例入选标准的60例患者随机分为观察组、对照组,每组30例。2组均给予氨茶碱、糖皮质激素、抗生素等对症治疗,对照组同时给予吸氧、气管切开、气管插管等对症治疗。观察组同时给予机械通气。观察2组治疗前后血气分析结果、肺功能等各项检测指标。结果临床控制率观察组为36.67%,对照组为20.00%,2组相比差异有统计学意义(P﹤0.05)。总有效率观察组为76.67%,对照组为66.67%。2组总有效率相比差异有统计学意义(P﹤0.05)。PaO2、PaCO2、SaO2等指标2组治疗前后组内相比差异有统计学意义(P﹤0.05);治疗后2组组间相比差异有统计学意义(P﹤0.05)。治疗后2组Cdyn、MVV、FEV0.3等指标均有明显差异(P﹤0.05),2组FVC相比差异无统计学意义(P﹥0.05)。结论机械通气联合药物治疗严重胸外伤所致呼吸窘迫综合征患者具有较好的临床疗效,可显著改善患者肺功能。
Objective To observe the clinical effect of mechanical ventilation on respiratory distress syndrome caused by severe chest trauma. Methods Sixty patients who met the criteria of the case were randomly divided into observation group and control group, 30 cases in each group. 2 groups were given aminophylline, glucocorticoid, antibiotics and other symptomatic treatment, while the control group were given oxygen, tracheotomy, tracheal intubation and other symptomatic treatment. The observation group was given mechanical ventilation at the same time. Before and after treatment, blood gas analysis results, lung function and other test indicators were observed. Results The clinical control rate was 36.67% in the observation group and 20.00% in the control group. There was significant difference between the two groups (P <0.05). The total effective rate was 76.67% in the observation group and 66.67% in the control group. There was significant difference between the two groups in total effective rate (P <0.05). PaO2, PaCO2, SaO2 and other indicators of two groups before and after treatment, the difference was statistically significant (P <0.05); after treatment there was significant difference between the two groups (P <0.05). There were significant differences in Cdyn, MVV and FEV0.3 between the two groups after treatment (P <0.05). There was no significant difference between the two groups in FVC (P> 0.05). Conclusion Mechanical ventilation combined with drug treatment of patients with respiratory distress syndrome caused by severe thoracic trauma has better clinical efficacy and can significantly improve lung function in patients.