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目的对低高密度脂蛋白-胆固醇(HDL-C)血症患者药物干预前后血浆一氧化氮合酶(Nitric oxide synthase,NOS)和一氧化氮(Nitric oxide,NO)进行研究,探讨低HDL-C血症致动脉粥样硬化的可能机制。方法根据血脂水平和颈动脉内膜-中层厚度(IMT)等选取119例(男69例,女50例)低HDL-C血症患者作为低HDL-C血症组和78例(男43例,女35例)正常人群作为健康对照组,分别测定受检人群(包括低HDL-C血症患者治疗达标后)血浆NOS(用化学比色法测定)和NO(用硝酸酶还原法测定)。结果与健康对照组比较,低HDL-C血症组血浆NOS(P<0.05)和NO(P<0.05)均显著降低,男性及女性亚组亦显著低于相应健康对照组(P<0.05);低HDL-C血症组(79例)治疗达标(HDL-C>1.04mmol/L)后,血浆NOS(P=0.041)和NO(P=0.038)均显著升高(包括男性及女性亚组P<0.05),而与健康对照组干预前后相比,无统计学意义(P>0.05)。结论低HDL-C血症患者血浆NOS和NO水平显著低于健康对照组(包括男性和女性亚组)并且治疗后(血浆HDL-C水平达标)较治疗前显著升高而与健康对照组干预前后相比无明显改变;低HDL-C可能通过NOS/NO途径参与介导动脉粥样硬化发生、发展的病理演变过程。
Objective To investigate the changes of plasma levels of plasma nitric oxide synthase (NOS) and nitric oxide (NO) in patients with low-density lipoprotein-cholesterol (HDL-C) Possible Mechanism of Atherosclerosis Induced by. Methods A total of 119 patients (69 males and 50 females) with low HDL-C were enrolled as subjects with low HDL-C and 78 males (43 males and 43 females) according to the level of blood lipid and carotid intima-media thickness (IMT) , 35 females) normal population as healthy control group were measured in the test population (including patients with low HDL-C sera after treatment compliance) plasma NOS (by chemical colorimetric assay) and NO (nitrate reduction assay) . Results Compared with healthy control group, plasma NOS (P <0.05) and NO (P <0.05) in low HDL-C group were significantly lower than those in healthy control group (P <0.05) ; Plasma NOS (P = 0.041) and NO (P = 0.038) were significantly elevated in HDL-C patients (HDL-C> 1.04mmol / L) Group P <0.05), but there was no significant difference between before and after intervention (P> 0.05). Conclusions Plasma NOS and NO levels in patients with low HDL-C are significantly lower than those in healthy controls (including male and female subgroups) and are significantly higher than those before treatment (plasma HDL-C levels) after treatment Low HDL-C may participate in the pathogenesis of atherosclerosis through the NOS / NO pathway.