雷诺定受体2(ryanodine receptor 2,RyR2)是心肌细胞肌浆网上主要的钙释放通道,主要参与心肌的兴奋收缩耦联过程,其基因突变及调控异常可导致心肌舒张期钙漏引起心律失常,甚至猝死。本文重点综述RyR2基因突变及调控异常引起心脏性猝死的机制,并对以后的研究提出建议,旨在为心脏性猝死的法医学诊断提供一种新的思路。 Ryanodine receptor 2 (RyR2) is the main Ca2 + release channel in cardiomyocyte sarcoplasmic reticulum, which is mainly involved in the process of excitatory and contractile coupling of cardiac muscle. Its gene mutation and abnormal regulation may lead to cardiac arrhythmia caused by diastolic calcium leak , Or even sudden death. This review focuses on the mechanisms of sudden cardiac death caused by mutations in RyR2 gene and its regulation, and makes recommendations for future studies to provide a new idea for forensic diagnosis of sudden cardiac death.