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目的探讨豚鼠感染鼠疫菌主要实质性脏器的病理改变。方法强毒鼠疫菌25 cfu/ml感染成体实验豚鼠鼠蹊部皮下。病死豚鼠立即取材,未病死豚鼠14 d分别处死并取材。取肝、脾、肺、肾及心等实质性脏器分离培养鼠疫菌,并制作病理切片观察病理改变。结果感染鼠疫菌的实验豚鼠肝、脾、肺、肾及心脏均分离出鼠疫菌;其组织巨检均有明显病理变化,镜检除心脏外均有明显的病理变化,呈炎性细胞增多,充血、出血、部分坏死等急性炎症变化。结论强毒鼠疫菌引起实验豚鼠急性炎症反应,豚鼠肝、脾、肺、肾、心等实质性脏器的病理变化显著。
Objective To investigate the pathological changes of major parenchymatous organs infected by Y. pestis in guinea pigs. Methods Inoculation of 25 cfu / ml attenuated Yersinia pestis subcutaneously in guinea pig groins. The dead guinea pigs were taken immediately and the uninjured guinea pigs were sacrificed and taken for 14 days respectively. Take the liver, spleen, lung, kidney and heart and other substantive organism Yersinia pestis isolated and cultured, and pathological sections were made to observe the pathological changes. Results Yersinia pestis was isolated from the liver, spleen, lung, kidney and heart of guinea pig infected with Yersinia pestis. The histopathological changes of the Yersinia pestis were observed in all the tissues of the guinea pig infected with Y. pestis. Congestion, bleeding, partial necrosis and other acute inflammatory changes. Conclusion The virulent Yersinia pestis caused the acute inflammatory reaction in guinea pigs. The pathological changes of the liver, spleen, lung, kidney and heart in guinea pigs were significant.