急性呼吸性酸中毒(简称急性呼酸)或慢性呼吸衰竭急性发作时,通常使用碳酸氢钠(NaHCO_3)进行纠正,但常效果不佳,甚至少数病例还会出现呼吸抑制的严重危象。现已证实NaHCO_3在纠酸时能与血液中的H~+反应生成CO_2,不但提高血液pH作用较小,而且能进一步增加CO_2潴留。有关NaHCO_3在急性呼酸使用过程中对脑脊液(CSF)pH的影响国内报道不多,本研究的目的旨在通过犬实验探讨急性呼酸时NaHCO_3对CSF pH的影响,以此而解释NaHCO_3在急性呼酸时做为纠酸剂所引起的呼吸抑制危象。 Acute respiratory acidosis (acute sour acidosis) or acute episodes of chronic respiratory failure, usually using sodium bicarbonate (NaHCO_3) to correct, but often ineffective, and even a few cases there will be severe respiratory depression. It has been confirmed that NaHCO3 can react with H ~ + in the blood to generate CO2 when correcting acidosis, which not only improves blood pH but also increases CO2 retention. The purpose of this study was to investigate the effect of NaHCO_3 on CSF pH during acute acidosis by explaining the effect of NaHCO_3 on the pH of cerebrospinal fluid (CSF) in the process of acute acidosis. Huoxu acid as a correction agent caused by respiratory depression crisis.