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花生四烯酸通过肾皮质及髓质的环加氧化酶及脂质加氧酶的作用,合成各种前列腺素(PG)和血栓素(TX),单及双羟基二十四烯酸(HETE)及白细胞三烯。肾PG主要由肾小球产生,人主要产生前列环素(PGI_2),人和鼠肾小球存在脂质加氧酶代谢产物(12-HETE和15-HETE)。血栓素A_2(TXA_2)收缩肾小动脉使肾血流量降低,使系膜细胞收缩,降低肾小球滤过率。血管收缩激素可促进肾脏PG生成,即血管紧张素Ⅱ、加压素及去甲基肾上腺素,促进有扩张血管作用的PGE:或PGI_2的合成,而PG可调节血管收缩激素引起血管收缩。
Arachidonic acid through the renal cortex and medulla ring plus oxidase and lipid oxygenase, the synthesis of a variety of prostaglandins (PG) and thromboxane (TX), mono and dihydroxy-tetracones (HETE ) And leukotrienes. Kidney PG is mainly produced by the glomerulus, which produces predominantly prostacyclin (PGI_2) and lipid and oxygenase metabolites (12-HETE and 15-HETE) in human and mouse glomeruli. Thromboxane A2 (TXA2) contracting the renal arteries to reduce renal blood flow, so that mesangial cells shrink and reduce glomerular filtration rate. Vasoconstrictors promote the production of PG in the kidneys, namely angiotensin II, vasopressin and norepinephrine, and promote the synthesis of PGE: or PGI_2 with vasodilatation. PG regulates vasoconstriction induced by vasoconstrictors.