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咯萘啶的水溶液经口灌胃给药,大鼠染尘3天后即给药治疗,一个月内肺组织病变基本是间质性肺炎、尘细胞浸润,而此时尘肺对照组大鼠肺组织已出现纤维细胞性结节。相应的肺门淋巴结的硬度、大小和肺湿重T/C比值(均小于0.75)与肺组织纤维化程度相一致。染尘1个月后给药治疗,高低剂量组的肺湿重T/C比值均远大于0.75,肺门淋巴结变化和肺纤维化程度与尘肺对照组相比没有明显区别。
An aqueous solution of pyronaridine by oral gavage, the rats dyed for 3 days after treatment, the lung tissue lesions within one month is interstitial pneumonia, dust cell infiltration, and pneumoconiosis control group rats lung tissue Fibroblastic nodules have emerged. The corresponding hilar lymph node hardness, size and lung wet weight T / C ratio (both less than 0.75) consistent with the degree of lung fibrosis. Doping dust after 1 month of treatment, high and low dose groups of lung wet weight T / C ratio was much greater than 0.75, hilar lymph node changes and degree of pulmonary fibrosis and pneumoconiosis control group no significant difference.