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目的 研究肠易激综合征 (IBS)病人外周血T淋巴细胞亚群比例和免疫球蛋白 (Ig)水平的变化 ,探讨IBS与机体免疫之间的关系。方法 应用流式细胞术测定IBS患者T 淋巴细胞亚群的比例 ,采用免疫散射比浊法测定患者Ig和补体 (C3、C4 )含量。结果 与健康对照组比较 ,IBS患者CD3+ 细胞数下降 ,C3、C4均偏低 ,但无统计学意义 (P >0 .0 5 )。腹泻型CD4 + 细胞数显著降低 (P <0 .0 1) ,CD8+ 细胞数显著升高 (P <0 .0 1) ,致CD4 /CD8比值下降 (P <0 .0 1) ;IgG、IgA相对增高 (P <0 .0 5 )。便秘型CD4 + 、CD8+ 细胞数均显著降低 (P <0 .0 5 ) ,但CD8+ 细胞抑制更明显 ,而使CD4 /CD8比值明显升高 (P <0 .0 5 ) ,此型患者IgA显著增高 (P <0 .0 5 )。结论 各型IBS患者T淋巴细胞亚群比例和Ig水平的变化 ,提示IBS患者的发病与机体的免疫异常有关。
Objective To study the changes of peripheral blood T lymphocyte subsets and immunoglobulin (Ig) levels in patients with irritable bowel syndrome (IBS) and to explore the relationship between IBS and immune system. Methods The proportion of T lymphocyte subsets in patients with IBS was determined by flow cytometry. Ig and complement (C3, C4) contents were measured by immune nephelometry. Results Compared with the healthy control group, the number of CD3 + cells in IBS patients decreased but both C3 and C4 were lower but not statistically significant (P> 0.05). The number of CD4 + cells was significantly decreased (P <0.01), the number of CD8 + cells was significantly increased (P <0.01), and the ratio of CD4 / CD8 was decreased (P <0.01) Relative increase (P <0.05). The number of CD4 + and CD8 + cells in constipation was significantly decreased (P <0.05), but the inhibition of CD8 + cells was more obvious and the ratio of CD4 / CD8 was significantly increased (P <0.05). IgA was significantly Increased (P <0.05). Conclusion The changes of T lymphocyte subsets and Ig levels in various types of IBS patients suggest that the pathogenesis of IBS is related to the abnormal immune system.