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目的 :探讨ACE基因多态性与脑梗死危险因素的关系。方法 :应用聚合酶链反应技术 (PCR)检测 312例上海地区正常人和32 5例脑梗死患者的ACE基因 ,并调查脑梗死患者危险因素。结果 :①ACEDD基因型在脑梗死患者中年龄≥ 5 0岁组频率为 0 2 46,高于对照组 0 15 1。DD :DⅠ +Ⅱ ,χ2 =5 84(P <0 0 5 ) ,差别有显著意义。②脑梗死患者中有高血压病史 73 8%、高血压病家族史48 6%、脑卒中家族史 32 3% ,明显高于其他危险因素。③ACE基因型与脑梗死患者的体重指数 (BMI)、血压、血糖等危险因素值差异无显著性 (P >0 0 5 )。结论 :ACEDD基因型可能是脑梗死的一个独立危险因素。高血压病、高血压病家族史、脑卒中家族史是脑梗死主要危险因素。ACE基因型与脑梗死危险因素关系需进一步研究
Objective: To investigate the relationship between ACE gene polymorphism and risk factors of cerebral infarction. Methods: Polymerase chain reaction (PCR) was used to detect the ACE gene in 312 cases of normal subjects and 325 cases of cerebral infarction in Shanghai and to investigate the risk factors of patients with cerebral infarction. Results: ① The frequency of ACEDD genotype in patients with cerebral infarction ≥ 50 years old was 0 2 46, which was higher than that of control group 0 15 1. DD: DⅠ + Ⅱ, χ2 = 5 84 (P <0 05), the difference was significant. ② Among the patients with cerebral infarction, 73.8% of hypertension history, 48.6% of family history of hypertension and 32.3% of stroke family history were significantly higher than other risk factors. ③ There was no significant difference in the risk factors of body mass index (BMI), blood pressure, blood glucose among patients with ACE genotype and cerebral infarction (P> 0.05). Conclusion: ACEDD genotype may be an independent risk factor for cerebral infarction. Hypertension, family history of hypertension and family history of stroke are the main risk factors of cerebral infarction. The relationship between ACE genotypes and risk factors of cerebral infarction needs further study