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目的:探讨血管内皮生长因子及一氧化氮在阻塞性睡眠呼吸暂停低通气综合征病理生理过程中的意义。方法:检测轻、中重度阻塞性睡眠呼吸暂停低通气综合征患者及单纯鼾症患者血清一氧化氮、血管内皮生长因子浓度,中重度患者经鼻持续气道正压通气治疗前后的一氧化氮、血管内皮生长因子含量变化。结果:阻塞性睡眠呼吸暂停低通气综合征患者一氧化氮浓度较单纯鼾症患者明显下降,血管内皮生长因子则明显升高,中重度患者经鼻持续气道正压通气治疗后一氧化氮浓度升高,血管内皮生长因子浓度下降。结论:阻塞性睡眠呼吸暂停低通气综合征患者血清血管内皮生长因子浓度升高,一氧化氮水平下降;经鼻持续气道正压通气治疗后,血管内皮生长因子浓度下降,一氧化氮水平增加。
Objective: To investigate the significance of vascular endothelial growth factor and nitric oxide in the pathophysiology of obstructive sleep apnea-hypopnea syndrome. Methods: The levels of serum nitric oxide and vascular endothelial growth factor in mild and moderate obstructive sleep apnea-hypopnea syndrome patients and patients with simple snore were measured. Nitric oxide was measured before and after nasal continuous positive airway pressure ventilation in moderate-severe patients , Vascular endothelial growth factor content changes. Results: The levels of nitric oxide in patients with obstructive sleep apnea-hypopnea syndrome were significantly lower than those in patients with simple snoring and the levels of vascular endothelial growth factor were significantly increased in patients with moderate-severe nasal continuous positive airway pressure after nitric oxide treatment Increased, the concentration of vascular endothelial growth factor decreased. CONCLUSIONS: Serum levels of VEGF and NO are decreased in patients with obstructive sleep apnea-hypopnea syndrome. After continuous nasal CPAP, the concentrations of VEGF and NO decreased .