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目的观察胺碘酮联用小剂量利尿剂治疗高血压合并阵发性房颤的临床效果。方法将原发性高血压合并阵发性房颤患者90例根据治疗方法不同分为2组,对照组42例给予胺碘酮治疗,试验组48例在对照组治疗的基础上给予小剂量利尿剂治疗。比较2组房颤转复成功率、1年内房颤复发率及治疗前后左心房内径变化。结果试验组患者72 h、1周内转复成功率均高于对照组,差异均有统计学意义(P<0.05)。2组患者3个月、6个月、1年内复发率比较差异均无统计学意义(P>0.05)。2组患者治疗前、治疗3个月、6个月、1年后左心房内径比较差异均无统计学意义(P>0.05)。结论胺碘酮联合小剂量利尿剂治疗高血压合并房颤能提高房颤转复成功率,但长期小剂量应用未观察到能降低复发率。
Objective To observe the clinical effect of amiodarone combined with low-dose diuretic on hypertension and paroxysmal atrial fibrillation. Methods Ninety patients with essential hypertension complicated with paroxysmal atrial fibrillation were divided into two groups according to different treatment methods, 42 patients in the control group were given amiodarone, and 48 patients in the experimental group were given low-dose diuretic Agent treatment. The successful rate of atrial fibrillation recovery, the recurrence rate of atrial fibrillation within 1 year and the change of left atrial diameter before and after treatment were compared. Results The successful rate of recovery in experimental group was higher than that of control group in 72 h and 1 week, the difference was statistically significant (P <0.05). There was no significant difference in recurrence rate between the two groups at 3 months, 6 months and 1 year (P> 0.05). There was no significant difference in the left atrial diameter between the two groups before treatment, 3 months, 6 months and 1 year after treatment (P> 0.05). Conclusions Amiodarone combined with low-dose diuretic in the treatment of hypertension and atrial fibrillation can improve the success rate of atrial fibrillation, but the long-term low-dose application has not been observed to reduce the recurrence rate.