核因子kappaB是一种重要的核内转录因子 ,在细胞炎性反应、免疫反应以及细胞凋亡等过程中起着举足轻重的作用。自 10多年前被发现开始 ,其结构、功能及作用机制就一直是研究的热点。作者就近年来在核因子kappaB结构和功能上的研究进展作一回顾 ,并简要介绍核因子kappaB的抑制因子和辅转录因子及其与其他转录因子之间的相互作用 Nuclear factor kappaB is an important nuclear transcription factor that plays an important role in inflammatory processes, immune responses and apoptosis. Since its discovery more than 10 years ago, its structure, function and mechanism of action have been the hot spots of research. The authors review recent advances in the structure and function of nuclear factor kappaB, and briefly describe the nuclear factor kappaB inhibitor and co-transcription factors and their interactions with other transcription factors