众所周知,由于许多原虫病和蠕虫病对药物产生抗性,预防比治疗更重要的观点已广为接受。近年来,在这一领域中的技术学和生物学方面的发展已令人瞩目。为此,本文综合308篇文献,从疫苗类型(减毒活疫苗、重组疫苗、合成肽疫苗和抗独特型疫苗),候选疫苗抗原的选择,疫苗提呈(佐剂、重组病毒和细菌载体),以及非特异性抗感染力和免疫疗法等方面提出设计疫苗应当考虑的问题和研制思路。 It is well-known that the prevention of drugs is more important than prevention because many protozoa and helminthiasis are drug resistant. In recent years, advances in technology and biology in this field have drawn great attention. To this end, 308 articles were synthesized from vaccine types (live attenuated vaccines, recombinant vaccines, synthetic peptide vaccines and anti-idiotypic vaccines), candidate vaccine antigen selection, vaccine presentation (adjuvant, recombinant virus and bacterial vectors) , As well as nonspecific anti-infectivity and immunotherapy and other aspects of the design of vaccines should consider the issues and development ideas.