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本发明提供了一种盐酸利多卡因的制备方法,属于麻醉剂合成技术领域。所述制备方法采用2.6-二甲酚为原料,采用Pd/C为主催化剂,2,6-二甲基环己酮为助催化剂,高温下用氨水进行液相胺化得到中间体2,6-二甲基苯胺;再采用甲醇钠、2,6-二甲基苯胺和N,N-二乙氨基乙酸甲酯为原料,于90-95℃下反应,边反应边蒸馏去除甲醇直至其无甲醇蒸出后,继续反应30min,冷却至室温,加入二氯乙
The invention provides a preparation method of lidocaine hydrochloride, belonging to the technical field of anesthetic synthesis. The preparation method adopts 2.6-xylenol as a raw material, adopting Pd / C as a main catalyst and 2,6-dimethylcyclohexanone as a cocatalyst, carrying out liquid phase amidation with ammonia water under high temperature to obtain the intermediate 2,6 - dimethylaniline; and then using sodium methylate, 2,6-dimethylaniline and N, N-diethylaminoacetic acid methyl ester as raw materials, at 90-95 ° C under reaction, the reaction was distilled off until the methanol Methanol after the distillation, the reaction was continued for 30min, cooled to room temperature, dichloroethyl