我们以往研究结果已表明,低氧叠加高二氧化碳引起脑血流的叠加反应,而低氧与低二氧化碳同时作用引起脑血流的下降。然而Paco_2到达一个什么程度,即通气增加到什么程度才能使低氧下的脑血流保持在低氧适应者水平(接近海平水平),这是本研究的目的。实验在雄性SD大鼠上进行,尿酯麻醉,在肌松剂作用下给予 Our previous findings have shown that hypoxia and hypercapnia cause a superimposed response to cerebral blood flow, whereas concurrent hypoxia and low carbon dioxide cause a decrease in cerebral blood flow. However, it is the purpose of this study to determine to what extent Paco_2 reached the level at which aeration was increased to maintain cerebral blood flow in hypoxic conditions at hypoxia adapters (near sea level). Experiments were performed on male Sprague-Dawley rats, anesthetized with urethane and given under the action of muscle relaxants