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目的：了解我院抗菌药物专项整治前后门诊内科抗菌药物的应用情况，为抗菌药物的合理应用提供参考。方法随机抽取我院抗菌药物专项整治前（2011年1～9月）及整治后（2012年1～9月）的门诊内科处方各6000张作比较，对抗菌药物在干预前后的使用、联用、不合理使用情况进行分析。结果干预前的门诊内科抗菌药物使用率为48.40%，干预后下降到16.60%，下降了31.80%；不合理用药由干预前的23.03%下降到干预后的12.95%，下降了10.08%。结论我院抗菌药物在干预前使用率偏高，干预后大大降低；体现了干预的有效性和可行性。“,”Objective: To provide the reasonable using reference of antimicrobial drugs, the application of antimicrobial drugs in outpatient in our hospital was investigated. Methods:6000 outpatient prescriptions were selected randomly from January to September in 2011and 2012 respectively, before and after the special rectification of antimicrobial drugs. The comparative analysis was taken on the usage, combination, irrational usage of antimicrobial drugs. Results: The rate of antibacterial drug usage in outpatient children was 48.40% down to 16.60%,with a decrease of 38.80% ; irrational drug usage was 23.03% down to 12.95% , with a decrease of 10.08%.Conclusions:With the special rectification of antimicrobial drugs, the using rate of antimicrobial drugs in our hospital decreased significantly, reflecting the effectiveness and feasibility of the intervention.