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目的采用倾向性评分法均衡早期乳腺癌患者保乳手术和改良根治手术两组间的混杂因素,评价早期乳腺癌的两种治疗方法的临床疗效。方法回顾性收集2009年1月~2013年12月在徐州医科大学附属医院接受乳腺癌手术治疗的女性患者。应用SPSS22.0中PSM模块采用1∶1最近邻匹配法、设定卡钳值为0.2进行倾向性匹配分析,以α=0.05作为检验水准。结果共收集286例患者,保乳手术组91例,改良根治手术组195例。经过倾向性评分匹配后,有52对患者获得匹配,匹配后9个观察协变量在两组间的分布均衡;保乳手术组和改良根治手术组的无复发生存率差异无统计学意义(P>0.05)。结论倾向性评分法可以有效的均衡保乳手术组和改良根治手术组间混杂因素的分布,患者的5年无复发生存率差异无统计学意义。
Objective To evaluate the clinical efficacy of two treatments of early breast cancer by using the propensity score method to balance the confounding factors between breast-conserving surgery and radical mastectomy in patients with early-stage breast cancer. Methods Retrospectively collected female patients undergoing breast cancer surgery at the Affiliated Hospital of Xuzhou Medical University from January 2009 to December 2013. The PSM module of SPSS 22.0 is applied to the 1: 1 nearest neighbor matching method and the caliper value of 0.2 is used to conduct propensity matching analysis. Α = 0.05 is used as the inspection level. Results A total of 286 patients were collected, breast conserving surgery group of 91 cases, modified radical mastectomy group of 195 cases. After the propensity score matching, 52 pairs of patients were matched, and the 9 observation covariates were balanced in the two groups after matching. The recurrence-free survival rate of breast conserving surgery group and modified radical surgery group was not statistically significant (P > 0.05). Conclusion The propensity score method can effectively balance the distribution of confounding factors between the breast conserving surgery group and the modified radical surgery group. There is no significant difference in the 5-year recurrence-free survival rate among the patients.