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为探讨性激素对鼠实验性肝癌的影响，复制DEN－AAF－PH肝癌动物模型．从形态计量角度．分别观察雌二醇、睾酮和去势手术对鼠实验性肝癌的作用。结果表明，雄性大鼠比雌性形成癌前增生性结节的数目多，体积大（P＜0．01）；雌二醇可使结书数目减少和体积减小．而睾酮与之相反；睾丸切除可减轻癌前病变．卵巢切除可加重癌前增生性结节的病变程度。性激素在鼠实验性肝癌的发生发展过程中起着重要作用。
To investigate the effect of sex hormones on experimental liver cancer in rats, a DEN-AAF-PH liver cancer animal model was reproduced. From the morphometric point of view. The effects of estradiol, testosterone, and castration on experimental liver cancer in mice were observed. The results showed that male rats had more precancerous proliferative nodules than females, and the volume was large (P<0.01). Estradiol could reduce the number of knots and reduce the volume. Testosterone is the opposite; testicular resection can reduce precancerous lesions. Ovariectomy can increase the extent of precancerous proliferative nodules. Sex hormones play an important role in the development of murine liver cancer.