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本文报道应用放射受体结合竞争法,及放射免疫法对44例疼痛病人和35例健康人血中内阿片样肽(EOLP)和亮氨酸脑啡肽(LEK)进行测定,并分别观察血中基础含量和针刺后的变化及其与中医辨证的关系。结果发现:(1) 内阿片样肽和亮氨酸脑啡肽在慢痛病人血中基础含量比同时测定的健康人水平低(P<0.001,P<0.05):(2) 阳虚病人血中LEK基础水平比非阳虚者低(P<0.02),而内阿片样肽在两型中差别不大;(3) 健康人针刺前后血中两类物质含量无明显变化。阳虚痛病人针刺后显著增加(P<0.05)。非阳虚痛病人则变化不显著。以上结果表明血中内阿片样肽和亮氨酸脑啡肽在慢痛的病理生理过程中起一定的作用。阳虚痛病人血中基础水平较低,针刺后显著增高与临床针刺镇痛阳虚病人疗效较好相符。本文不但为针刺镇痛与内阿片肽关系提供人体血中变化资料,并可进一步结合中西医理论,探讨中医辨证的物质基础。
This article reports the determination of blood endo-opioid peptide (EOLP) and leucine enkephalin (LEK) in 44 patients with pain and 35 healthy subjects by radioimmunoassay and radioimmunoassay. The levels of blood In the basic content and after acupuncture changes and its relationship with traditional Chinese medicine syndrome differentiation. The results showed that: (1) The contents of endo-opioid peptide and leucine-enkephalin in the blood of chronic pain patients were lower than those of healthy people (P <0.001, P <0.05); (2) The level of LEK was lower than that of non-yang (P <0.02), while the content of endo-opioid peptide was not different between the two types. (3) There was no significant change in the contents of two substances before and after acupuncture in healthy people. Yang hypokalemia patients after acupuncture significantly increased (P <0.05). Non-Yang virtual pain patients did not change significantly. The above results indicate that the blood endo-opioid peptide and leucine enkephalin play a role in the pathophysiological process of slow pain. Yang deficiency pain in patients with lower blood levels, significantly increased after acupuncture and acupuncture analgesic yang patients with better efficacy. This article not only provides information about human blood changes in the relationship between acupuncture analgesia and endogenous opioid peptides, but also further integrates Chinese and Western medicine theory to explore the material basis of TCM syndrome differentiation.