本文首次报道合成α-细辛脑的人体各项药物动力学参数。10名健康志愿者单剂量口服“α-细辛脑120mg,采用静脉置留针取血,反相高效液相色谱法测定α-细辛脑血中浓度。药时曲线呈二室模型,其清除半衰期3.5±1.0h,达峰时0.91±0.29h,峰浓度120±116ng/ml,药时曲线下面积149±95ng·h/ml,吸收速度常数4.1±2.8h~(-1)。结果表明,该药口服吸收快,在人体内分布广泛,并提示存在个体差异。 This article first reported the synthesis of α-asarone brain pharmacokinetic parameters. 10 healthy volunteers oral single-dose "α-asarone 120mg, the use of intravenous needle blood, reverse phase high performance liquid chromatography determination of α-asarone cerebral blood concentration. Drug curve was a two-compartment model, the removal of The half-life was 3.5 ± 1.0h, the peak time was 0.91 ± 0.29h, the peak concentration was 120 ± 116ng / ml, the area under the curve was 149 ± 95ng · h / ml and the absorption rate constant was 4.1 ± 2.8h ~ (-1) The drug is absorbed orally quickly and is widely distributed in the human body and suggests there are individual differences.