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目的探讨0~7月龄儿童中麻疹易感因素,探索可能对其采取的保护措施。方法选取常州市范围内在2009-2013年发病的0~7月龄儿童,采用病例对照研究的方法,就病例和对照的发病与就诊情况、可能的暴露史、居住地和旅行史、既往麻疹患病史、卫生服务情况、社会人口学和经济学信息等内容进行入户个案访谈调查。结果单因素及多因素分析结果显示:发病前7~21 d医院暴露史(OR=8.976,OR95%CI=4.087~19.713)、尤其是地市级(OR=8.00,OR95%CI=2.14~29.85)和县区级(OR=6.33,OR95%CI=1.81~22.11)医院暴露史以及病人接触史(OR=11.4,OR95%CI=1.207~107.653)是0~7月龄儿童麻疹发病的危险因素。结论加强传染源的管理,防止医源性感染,开展育龄妇女、流动人口等成人强化免疫是目前消除0~7月龄儿童麻疹的有效手段。
Objective To explore the measles susceptibility factors in children aged 0-7 months and explore possible protective measures. Methods Children aged 0 ~ 7 months who were diagnosed in Changzhou from 2009 to 2013 were selected. A case-control study was conducted. The incidence and treatment of cases and controls, possible exposure history, place of residence and travel history, previous measles Medical history, health services, social demography and economics information such as home visits interview. Results The results of univariate and multivariate analysis showed that the hospital history of 7-21 days before onset (OR = 8.976, OR 95% CI = 4.087-19.713), especially at prefecture level (OR = 8.00, OR 95% CI = 2.14-29.85 ) And county-level (OR = 6.33, OR 95% CI = 1.81-22.11) hospital exposure and patient exposure history (OR = 11.4, OR 95% CI = 1.207-107.653) were the risk factors for measles in children aged 0-7 months . Conclusion Strengthening the management of infectious sources, preventing iatrogenic infection, and carrying out intensive immunization among women of childbearing age and floating population are the effective measures to eliminate measles in children aged 0-7 months.