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目的:对9种流感病毒抗原快速检测试剂盒(rapid influenza virus diagnostic tests，RIDTs)的灵敏度进行评价。方法:季节性流感毒株收集后，通过TCIDn 50(组织细胞半数感染量)和病毒核酸序列测定分别确定病毒滴度及型别；流感毒株进行系列稀释后，使用流感病毒抗原快速检测试剂盒进行检测，以评价不同试剂的灵敏度。n 结果:不同试剂对同一株病毒的检出灵敏度差异最大为32倍稀释度(>10n 1 TCIDn 50/ml)；同一种试剂对不同型别、亚型/系流感病毒的检出灵敏度不同。n 结论:市场上的RIDTs灵敏度存在差别；使用多株不同流感型别、不同亚型/系的流感病毒将有助于对RIDTs产品质量进行全面评价和控制。“,”Objective:To evaluate the analytical sensitivity of nine rapid influenza virus antigen diagnostic tests (RIDTs).Methods:Human seasonal influenza viruses were collected and amplified. Gene sequencing was performed and TCIDn 50 were tested. Evaluation of nine RIDTs for the analytical sensitivity was performed after the subsequent dilution of human seasonal influenza A H3N2, H1N1, and influenza B viruses.n Results:RIDTs offers lower sensitivity than the nucleic acid amplification test. RIDTs overall had different analytical sensitivity based on the detection of the same isolate, and the difference between result was more than 10n 1 TCIDn 50/ml. Each RIDT had variable levels of positivity with different influenza subtypes/lineages.n Conclusions:The study demonstrated that the analytical sensitivity of RIDTs varies.