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目的探讨血清胱抑素C(CysC)在早期肾损伤中的检测意义及其防治措施。方法将100例血清CysC正常的早期肾脏病患者随机分为A组、B组,每组50例。两组患者均积极给于原发病治疗,B组患者加用羟苯磺酸钙胶囊或胰激肽原酶。观察期为12个月,观察指标为血清CysC、肌酐(Scr)、尿素氮(BUN)、内生肌酐清除率(Ccr),检测时间为治疗前、治疗后3个月、6个月、9个月、12个月。结果两组患者血清CysC异常的改变均明显早于Scr及Ccr的变化;B组患者CysC、Scr、Ccr出现异常均晚于A组,差异有统计学意义(P<0.05)。结论血清CysC较Scr、Ccr能更早期、更准确地反映GFR的改变;改善肾脏微循环治疗有利于防治血清CysC异常。
Objective To investigate the significance of serum cystatin C (CysC) in early renal injury and its prevention and treatment. Methods 100 patients with early stage renal disease with normal serum CysC were randomly divided into group A and group B, with 50 cases in each group. Two groups of patients are actively given to the treatment of primary disease, B group with calcium dobesilate or pancreatic kallikrein. The observation period was 12 months. The indexes of observation included serum CysC, creatinine (Scr), blood urea nitrogen (BUN) and endogenous creatinine clearance (Ccr). The detection time was 3 months, 6 months, 9 months Months, 12 months. Results The abnormal changes of serum CysC in both groups were significantly earlier than those in Scr and Ccr. The abnormalities of CysC, Scr and Ccr in group B were later than those in group A, with significant difference (P <0.05). Conclusions Serum CysC can reflect the change of GFR earlier than Scr and Ccr, and improve renal microcirculation treatment is beneficial to the prevention and treatment of serum CysC abnormality.