采用DEAE-52及葡聚糖凝胶G-100柱层析获得了具有抗氧化活性的苦瓜多糖(MCP)组分,通过构建小鼠四氯化碳肝损伤模型探讨了苦瓜多糖对肝损伤的防护作用。研究结果表明,纯化后的苦瓜多糖对超氧阴离子自由基清除率达82%,并能使肝损伤小鼠血清中的ALT和AST活性下降幅度分别达到10.6%及30.7%,肝匀浆中SOD、GSH-PX活性上升幅度分别为33.33%和26.62%,MDA含量则下降了25.62%。提示苦瓜多糖对肝损伤具有一定防护作用,保肝活性与海王金樽相近。 The components of Momordica charantia polysaccharides (MCP) with antioxidant activity were obtained by DEAE-52 and Sephadex G-100 column chromatography. The effects of polysaccharides from Momordica charantia on hepatic injury Protective effect. The results showed that purified purified bitter polysaccharide scavenging rate of superoxide anion free radical reached 82%, and the hepatic injury mice serum ALT and AST decreased by 10.6% and 30.7%, respectively, liver homogenate SOD , GSH-PX activity increased by 33.33% and 26.62%, MDA content decreased by 25.62%. Tips Momordica charantia polysaccharide on liver injury has a protective effect, liver activity similar to the sea King bottles.