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目的 探讨解脲支原体 (UU)、沙眼衣原体 (CT)感染与自然流产的相关性 ,为临床决策提供依据。对女性生殖道与宫内胚胎间UU ,CT感染的关系进行评价。方法 自然流产 (研究组 )和人工流产 (对照组 )妇女各 30例 ,留取宫颈管分泌物和绒毛组织 ,采用聚合酶链反应技术 (PCR)进行UU -DNA ,CT -DNA检测。随机抽取了其中的 8例绒毛标本进行光镜和电镜的组织学检查。结果 生殖道UU ,CT检出阳性者研究组分别为 10 0 % ,33 3 % ,对照组分别为 2 0 0 % ,43 3 % ,差异无显著性 (P >0 0 5 )。绒毛UU ,CT检出阳性者研究组分别为 16 7% ,2 6 7% ,对照组为 33 3 % ,30 0 % ,差异无显著性 (P >0 0 5 )。生殖道UU ,CT阳性者 37 9%绒毛中检出同种病原体 ,阴性者中 48 4%绒毛UU ,CT阳性。两者差异无显著性 (P >0 0 5 )。组织学检查未发现UU ,CT感染的绒毛标本具特异性改变。结论 生殖道及妊娠组织的UU ,CT感染并不增加早期妊娠丢失 ,宫颈管UU ,CT的存在不是导致宫内胚胎感染的决定因素。
Objective To investigate the correlation between UU and CT infection and spontaneous abortion and provide the basis for clinical decision-making. The relationship between female genital tract and intrauterine embryo UU, CT infection was evaluated. Methods Thirty cases of spontaneous abortion (study group) and induced abortion (control group) women were collected. Cervical tube secretions and villi tissues were collected. UU-DNA and CT-DNA were detected by polymerase chain reaction (PCR) Eight of them were randomly selected for histological examination by light microscopy and electron microscopy. Results The prevalence of UU and CT in the genital tract was 10 0% and 33 3% in the study group and 200% and 43 3% in the control group, respectively. There was no significant difference (P> 0.05). There was no significant difference between the two groups (16.7%, 26.7%, 33.3% and 30.0% respectively) in the positive UU and CT samples. Reproductive tract UU, CT positive 37 9% of villi were detected in the same pathogen, 48 4% of the negative villus UU, CT positive. There was no significant difference between the two groups (P> 0.05). Histological examination found no UU, CT-infected villi specimens with specific changes. Conclusion UU and CT infection in the genital tract and pregnancy does not increase the loss of early pregnancy. The presence of cervical UU and CT is not the determinant of intrauterine embryo infection.