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为研究多发性骨髓瘤（MM）与反应性浆细胞增多症（RP）、MMIB与MMNA以及MM治疗前后的骨髓浆细胞嗜银蛋白染色（AgNOR）形态颗粒数量的变化，用AgNOR技术．测定各级AgNOR形态及颗粒数量。结果显示，AgNOR形态在MM组中有单一型、弥漫型、聚集型、核仁形，在RP组中只有单一型，AgNOR颗粒均数在MM组中为6．21±4．12，RP组为202±063，两组间有非常显著性差异（P＜0．001）；MMⅢB和ⅢA组，形态及颗粒均数无差异。17例MM治疗前、后各种形态中颗粒比较差别有显著性（P＜0．001）。提示骨髓中浆细胞AgNOR形态及颗粒数量对鉴别良、恶性浆细胞具有一定临床意义，同时也证实了AgNOR法对了解MM中浆细胞增殖水平及预后是一个简单有效的参考指标。
In order to study the change of granulocyte plasma silver staining protein (AgNOR) morphology before and after treatment of multiple myeloma (MM) and reactive plasmacytosis (RP), MMIB and MMNA, and MM, AgNOR technology was used. AgNOR morphology and particle counts were determined at each stage. The results showed that the AgNOR morphology was single, diffuse, aggregated, and nucleolar in the MM group. There was only a single type in the RP group. The mean AgNOR granules were 6.21±4.12 in the MM group. At 202±063, there was a significant difference between the two groups (P<0.001). In the MMIIIB and IIIA groups, there was no difference in the morphology and the average number of particles. There were significant differences in the granules of various forms before and after MM treatment (P<0.001). It is suggested that AgNOR morphology and particle number of plasma cells in bone marrow have certain clinical significance for the identification of benign and malignant plasma cells. It is also proved that AgNOR method is a simple and effective reference index for understanding the plasma cell proliferation and prognosis in MM.