肝素作为抗凝剂,临床上主要用于急性血栓病、急性心肌梗塞以及血管或心脏外科等。肝素口服是无效的,必须静脉或肌肉给药。由于肝素静脉给药后在体内维持抗凝作用的时间较短,因此治疗中需持续地静脉滴注或每隔3～4小时重复给药,这就为临床用药带来许多不便。为了改变肝素的给药途径和延长肝素在体内的有效血药浓度,我们制备了肝素脂质体,并对肝素脂质体的药理活性进行了初步研究, Heparin as anticoagulant, clinically used mainly for acute thrombosis, acute myocardial infarction and vascular or cardiac surgery. Oral heparin is ineffective and must be administered intravenously or intramuscularly. Because heparin intravenous administration in the body to maintain anticoagulant effect is shorter, so the need for continuous intravenous infusion or repeated every 3 to 4 hours, which brings many inconveniences for clinical use. In order to change the route of administration of heparin and prolong the effective blood concentration of heparin in the body, we prepared heparin liposomes and studied the pharmacological activities of heparin liposomes.