双酚A(bisphenol A)是一种常见的环境内分泌干扰物(EDCs),它常用作聚碳酸酯塑料、聚苯乙烯树脂和牙科密封剂的原料。BPA的环境污染很广泛,可通过水和食物进入人体,95%人群的尿样能够检测到BPA。流行病学资料和动物实验研究表明,BPA能够快速穿透胎盘屏障和血脑屏障,并且孕期BPA暴露能够致子代心理行为发育改变。本文将重点从表观遗传学、基因组与非基因组效应、氧化应激、多巴胺系统、突触数量和可塑性改变等方面阐述孕期BPA暴露对子代心理行为发育影响的机制。 Bisphenol A, a common environmental endocrine disruptor (EDCs), is commonly used as a raw material for polycarbonate plastics, polystyrene resins and dental sealants. BPA has a wide range of environmental contaminants that can enter the body through water and food, and BPA can be detected in urine samples from 95% of the population. Epidemiological data and animal experiments show that BPA can quickly penetrate the placental barrier and the blood-brain barrier, and BPA exposure during pregnancy can cause changes in offspring’s psychological and behavioral changes. This article will focus on the mechanism of gestational BPA exposure on the psychological and behavioral development of offspring in terms of epigenetics, genomic and non-genomic effects, oxidative stress, dopamine system, changes in synaptic numbers and plasticity.