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目的探讨子宫内膜浆液性乳头状癌(uterinepapillaryserouscarcinoma,UPSC)的临床病理特征,以及合理的治疗方法。方法对2000年1月~2004年12月我院收治的34例UPSC进行回顾性研究,对其发病趋势、危险因素、临床表现、病理特征、目前诊断方法和治疗方案进行统计学分析。结果Ⅲ、Ⅳ期患者占44·1%,深肌层及以上浸润者占70·6%。64·7%患者术后病理分期高于术前临床分期。91·2%患者雌孕激素受体阴性。全部患者手术治疗,绝大部分术后辅以化疗、放疗,生存率较以往文献提高,但仍较其他类型子宫内膜癌差。结论UPSC不同于其他类型子宫内膜癌,其特殊的生物学行为和病理特征决定UPSC具有高度恶性表现。随着对其逐步认识,目前诊断和治疗均较以往有较大提高。
Objective To investigate the clinicopathological characteristics of uterine papillary carcinoma (UPSC) and its reasonable treatment. Methods From January 2000 to December 2004, 34 cases of UPSC admitted to our hospital were retrospectively studied. The incidence trends, risk factors, clinical manifestations, pathological features, current diagnosis methods and treatment regimens were analyzed statistically. Results The patients in stage Ⅲ and Ⅳ accounted for 44.1%, while those in deep muscle layer and above accounted for 70.6%. 64.7% patients were higher than the preoperative clinical stage staging. 91.2% patients were negative for estrogen and progesterone receptors. Surgical treatment of all patients, the vast majority of postoperative adjuvant chemotherapy, radiotherapy, survival rate than the previous literature to improve, but still worse than other types of endometrial cancer. Conclusion UPSC is different from other types of endometrial cancer, its special biological behavior and pathological characteristics of UPSC have a high degree of malignancy. With its gradual understanding, the current diagnosis and treatment have greatly improved than in the past.