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目的通过Meta分析探讨细胞周期素依赖激酶5调节亚单位相关蛋白1类似物1(CDKAL1)基因rs10946398 C/A多态性位点与2型糖尿病易感性的关系。方法通过系统检索Pub M ed、Web of Science、CNKI、万方数据库、维普数据库等中英文数据库,纳入2007~2015年有关CDKAL1(rs10946398 C/A)基因多态性与2型糖尿病相关性的研究,以2型糖尿病组和正常对照组基因分布的OR值为统计量,应用Rev Man 5.3软件对研究结果进行异质性检验和相关数据的合并,最终纳入16篇文献。结果 CDKAL1基因rs10946398 C/A多态性位点与2型糖尿病相关联,不同人种在不同遗传模型下其相关程度不同,其中等位基因遗传模型(OR:1.58,95%CI:1.30~1.93)、隐形遗传模型(OR:1.14,95%CI:1.09~1.20)、显性遗传模型(OR:1.05,95%CI:1.01~1.09)、纯合遗传模型(OR:1.19,95%CI:1.13~1.26)差异均有统计学意义(P<0.01)。结论 C等位基因的风险比率显著高于A等位基因,提示CDKAL1基因rs10946398 C等位基因可能会增加人群患2型糖尿病的易感性。
Objective To investigate the relationship between rs10946398 C / A polymorphism of CDKAL1 gene and the susceptibility to type 2 diabetes mellitus (T2DM) by Meta-analysis. Methods The Chinese and English databases such as Pub M ed, Web of Science, CNKI, Wanfang database and VIP database were searched systematically to investigate the association between CDKAL1 (rs10946398 C / A) polymorphism and type 2 diabetes mellitus . The OR of gene distribution in type 2 diabetes mellitus and normal controls was used as a statistical measure. Rev Man 5.3 software was used to carry out heterogeneity test and the data merging. Finally, 16 articles were included. Results The rs10946398 C / A polymorphism of CDKAL1 gene was associated with type 2 diabetes mellitus. The relative degree of different genetic types was different in different races. The allelic genetic model (OR: 1.58, 95% CI: 1.30-1.93 ), Invisible genetic model (OR: 1.14, 95% CI: 1.09-1.20), dominant genetic model (OR: 1.05, 95% CI: 1.01-1.09) 1.13 ~ 1.26) were statistically significant differences (P <0.01). Conclusion The risk ratio of C allele is significantly higher than that of A allele, suggesting that rs10946398 C allele of CDKAL1 gene may increase the susceptibility of people to type 2 diabetes.