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目的：为提高对男性狼疮性肾炎（ＬＮ）的认识，减少误、漏诊。方法：收集住院的５４例男性ＬＮ和同期４８２例女性患者的临床资料行统计学对比分析。结果：（１）发病年龄构成的比较：女性２０～４０岁占总数的６９．３％，而男性只占同龄段的５１．８％（Ｐ＜０．０１）。（２）肾脏损害：女性多数患者肾内、外损害同时出现，而男性多数患者（４７／５４）肾损害先于肾外损害；男性出现大量蛋白尿者显著高于女性患者（Ｐ＜０．０１）。（３）肾外临床表现：男性以不规则发热、关节疼痛、皮疹、胸积液和周围神经炎多为常见，而女性则以蝶形红斑、脱发、精神神经症状及雷诺氏现象表现为常见。结论：男性与女性ＬＮ的临床表现有较明显差别。
Objective: To improve the understanding of male lupus nephritis (LN), reduce errors and missed diagnosis. Methods: The clinical data of 54 male LN patients and 482 female patients during the same period were collected and compared statistically. Results: (1) Comparison of the age of onset: women aged 20-40 accounted for 69.3% of the total, while men only accounted for 51.8% of the same age (P <0.01). (2) Kidney damage: The majority of female patients had renal and external injuries simultaneously, while the majority of male patients (47/54) had renal damage before renal damage. Men with large proteinuria were significantly higher than female patients (P <0. 01). (3) extrahepatic clinical manifestations: men with irregular fever, joint pain, rash, pleural effusion and peripheral neuritis are more common, while women with butterfly erythema, hair loss, neurological symptoms and Raynaud’s phenomenon is common . Conclusion: The clinical manifestations of LN in males and females are quite different.