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目的:评估1 000 IU低剂量hCG在控制性卵巢刺激(COS)过程中诱发卵泡成熟的作用。方法:35例接受IVF/ICSI-ET治疗的患者进行35个周期的COS。在诱发卵泡成熟日,肌肉注射hCG1 000 IU;并按照血E2水平分为卵巢正常反应组(E2<3 000 pg/ml,A组,12例)和卵巢高反应组(E2≥3 000 pg/ml,B组,23例),统计分析IVF/ICSI-ET结局。结果:35例患者均获得成熟卵母细胞并进行了胚胎移植,平均获卵数为13.5±7.7枚,平均成熟卵母细胞数为11.6±6.7枚,平均受精卵数为10.8±5.6枚,平均胚胎数为10.0±5.6枚,平均移植胚胎数1.9±0.2枚,平均冷冻保存胚胎数为4.3±3.3枚,临床妊娠率A组为50.00%,显示高于B组(30.43%)(P<0.05),继续妊娠率A组为41.67%,显示高于B组(26.09%)(P<0.05);所有患者均未发生无中/重度卵巢过度刺激综合征。A组与B组相比较,获卵率、受精率、优质胚胎率及早期流产率均无统计学差异(P>0.05)。结论:1 000 IU的低剂量hCG能够在COS过程中诱发卵泡成熟,不仅适应于卵巢反应高者,而且也适应于卵巢反应正常者。
OBJECTIVE: To evaluate the role of 1 000 IU low-dose hCG in inducing follicular maturation during controlled ovarian stimulation (COS). Methods: 35 patients with IVF / ICSI-ET received 35 cycles of COS. The intramuscular injection of hCG1 000 IU intramuscularly was divided into normal ovarian response group (E2 <3 000 pg / ml, group A, 12 cases) and high ovarian response group (E2≥3 000 pg / ml, group B, 23 cases), statistical analysis of IVF / ICSI-ET outcome. Results: All the 35 patients received embryo transfer. The average number of oocytes retrieved was 13.5 ± 7.7. The average number of mature oocytes was 11.6 ± 6.7. The average number of oocytes was 10.8 ± 5.6. The mean The number of embryos was 10.0 ± 5.6, the average number of embryos transferred was 1.9 ± 0.2. The average number of frozen embryos was 4.3 ± 3.3. The clinical pregnancy rate in group A was 50.00%, which was higher than that in group B (30.43%) (P <0.05) ). The rate of continuing pregnancy in group A was 41.67%, which was higher than that in group B (26.09%) (P <0.05). No moderate / severe ovarian hyperstimulation syndrome did not occur in all patients. There was no significant difference in the ovulation rate, fertilization rate, good embryo rate and early miscarriage rate between group A and group B (P> 0.05). Conclusion: 1 000 IU low-dose hCG can induce follicle maturation in COS, which is not only suitable for those with high ovarian response but also suitable for those with normal ovarian response.