Characterization of in vitro and in vivo metabolism of AG-024322, a novel cyclin-dependent kinase (C

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Uncontrolled cell proliferation is the hall mark of many cancers, and is typically manifested by a deregulation of the cell-division cycle. CDKs play critical roles in regulating cell cycle, apop- tosis and cell differentiation. AG-024322 is a multitarget
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