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性焦虑症妇女需长期接受大量雄激素治疗,如果使用雄激素可致卵巢发生与多囊卵巢综合征(PCO)患者相似的组织病理学变化,则证明雄激素是造成多囊卵巢结构改变的独立因素。实验包括三组妇女。第一组为10名性焦虑患者(20.4±1.6岁),每间隔2周肌内注射200mg庚酸睾丸素(T)油剂,共持续14个月至7年。其中8名妇女在雄激素治疗前周期规则,另外2名周期不规则。雄激素治疗过程中,患者出现完全闭经和男性化,以后进行性的再指定均行双侧乳房、子宫阴道及双侧附件切除术。第二组是3名PCO患者(33.0±2.3岁),行卵巢楔形切除术后,组织学检查证明患者卵巢的卵泡膜细胞增多、间质增生及白膜增厚。
Women with sexual anxiety require prolonged androgen therapy, and if androgen is used to induce ovarian histopathological changes similar to those in patients with PCO, it is demonstrated that androgens are independent of the structural changes of the polycystic ovary factor. The experiment included three groups of women. The first group consisted of 10 patients with sexual anxiety (20.4 ± 1.6 years) and intramuscular injection of 200 mg testosterone heptanoate (T) oil every 2 weeks for 14 months to 7 years. Eight women were regular before androgens and the other two were irregular. During androgen therapy, the patient developed complete amenorrhea and masculinity, and subsequent redesignations were performed on bilateral breasts, uterine vagina and bilateral accessory resections. The second group consisted of 3 PCO patients (33.0 ± 2.3 years). After ovariectomy, histological examination showed that the ovarian follicular cells, interstitial hyperplasia, and tunica albuginea thickened.