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目的 进一步阐明微量元素硒镉含量异常时心肌细胞损害的机理。方法 用细胞内微电极技术分别观察了 :正常对照、单纯高Cd、高Cd高维生素C、低Se高Cd、低Se高Cd伴高维生素C饲料饲养 14w后大鼠心肌细胞电生理的变化。结果 单纯高镉组无变化 ;低硒并高镉组RP、APA降低 ,APD50 、APD90 明显延长 ;低Se高镉高维生素C组仅RP降低 ,APA、APD与对照组相比差异无显著性意义。结论 低硒并高镉可明显改变心肌细胞的电生理特性 ,维生素C可以对抗低Se并高Cd所致的这种变化。
Objective To further elucidate the mechanism of cardiomyocyte damage induced by trace element selenium and cadmium. Methods The intracellular microelectrode technique was used to observe the electrophysiological changes of cardiomyocytes in normal control, high Cd, high Cd high vitamin C, low Se high Cd and low Se high Cd with high vitamin C diet for 14 weeks respectively. The results showed that there was no change in the high-cadmium group alone. The RP and APA in the low-selenium and high cadmium group were decreased, while the APD50 and APD90 were significantly prolonged. . Conclusion Low selenium and high cadmium can significantly change the electrophysiological characteristics of cardiomyocytes. Vitamin C can resist this change caused by low Se and high Cd.