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[目的]探讨反流性食管炎(RE)和非糜烂性胃食管反流病(NERD)合并功能性消化不良(FD)患者反流症状及生活质量特点。[方法]该研究为多中心临床研究,在济南市的三家医院同期入选RE并FD 35例,NERD并FD73例。均符合内镜下RE的诊断标准,无RE者则为24 h食管pH监测阳性的NERD。进行反流症状及生活质量问卷调查并记录积分,然后对上述资料进行统计比较分析。[结果]①胃食管反流病(GERD)和FD病因尚不清楚,但症状可互相重叠。②NERD并FD临床反流症状积分(13.8±2.2)分,患者尽管没有可见的食管糜烂,但比RE并FD[(10.5±1.9)分]患者重(P<0.01),NERD并FD与RE并FD比较,在活力、躯体疼痛和总体健康3个维度上前者低于后者(P<0.01),余维度无统计学意义。[结论]①GERD和FD病因可能具有共同的神经胃肠病学基础。②NERD并FD患者反流症状严重,可能与NERD患者食管内脏高敏感性有关,对生活质量影响更大。
[Objective] To investigate the reflux symptom and quality of life in patients with reflux esophagitis (RE) and non-erosive gastroesophageal reflux disease (NERD) with functional dyspepsia (FD). [Methods] This study was a multicenter clinical study. Three hospitals in Jinan City were enrolled in this study. Among them, 35 were RE and FD, and 73 were NERD and FD. All met the diagnostic criteria of endoscopic RE, while non-RE was 24 h esophageal pH monitoring positive NERD. Reflux symptoms and quality of life questionnaire survey and record points, and then statistical analysis of the above data. [Results] ① The etiology of gastroesophageal reflux disease (GERD) and FD is not clear, but the symptoms may overlap each other. ②InnerD FD clinical reflux symptom score (13.8 ± 2.2), patients with severe esophageal erosions were more severe than those with RE and FD (10.5 ± 1.9) points (P <0.01) FD, the former was lower than the latter in vitality, body pain and general health (P <0.01), and the remaining dimensions were not statistically significant. [Conclusion] ① The etiology of GERD and FD may have the same basis of neural gastroenterology. ②NERD and FD patients with severe reflux symptoms may be associated with high sensitivity of esophageal visceral NERD patients, have a greater impact on quality of life.